Bayer HealthCare Rapidlab 800 - Manual (Page 557)

Performance Characteristics EĆ31
Lactate Biosensor Interfering Substances
To test for interferences, serum was spiked with a potentially interfering substance
up to the test concentration shown in the following tables. The interference was
calculated by comparing the spiked sample to an unspiked sample immediately
preceding it. To evaluate the interference from fluoride/oxalate, the blood was
drawn in grey-top tubes and compared to the lactate recovery in heparinized blood.
The following table lists substances that were found not to interfere with the lactate
measurement. At the concentrations listed, these compounds produced less than
0.3 mmol/L (2.7 mg/dL) error in the recovered lactate concentration.
Table EĆ26.āăSubstances Showing No Detectable Interference
Substance Concentration Tested
Chlorpromazine 17 mg/dL
Dopamine 1 mg/dL
Ethanol 350 mg/dL
Salicylate 50 mg/dL
Sodium Nitroprusside 70 mg/dL
Thiocyanate 80 mg/dL
Heparin 20,000 U/dL
Epinephrine 2 mg/dL
Norepinephrine 2 mg/dL
Phenobarbital 15 mg/dL
Glutamate 16 mg/dL
Hetastarch 30%
Acetoacetate 40 mg/dL
Ascorbate 8 mg/dL
Dilantin 14 mg/dL
(Continued)