ITC IRMA TruPoint Blood Analysis System - Manual (Page 127)

A.3
INTERFERENCES
Interference studies were based on NCCLS EP7-P. Serum or whole blood
was spiked with potentially interfering substances. The concentrations tested
and the expected effects are shown below.
Chloride
Substance (concentration) Expected Effect
SCN
(17 mmol/L)
Decrease Cl
- by 12 mmol/L
BUN
Substance (concentration) Expected Effect
SCN
(17 mmol/L)
Decrease BUN by 2 mg/dL
Glucose
Substance (concentration) Expected Effect
Glutathione
(1 mg/dL) Increase glucose by 10% at the 280
mg/dL glucose level
Hydroxy Urea
(500 umol/L) Increase glucose by 100% at the 120
mg/dL glucose level, and by 15% at
the 325 mg/dL glucose level
Iodoacetate
(900 mg/dL) Increase glucose by >300% at the
120 mg/dL glucose level, and by
25% at the 330 mg/dL level
Isoniazide
(7 mg/dL) Increase glucose by 10% at the 80
mg/dL glucose level
Pralidoxime Iodide (PAM)
(16 mg/dL) PAM concentrations of 16 mg/dL
and higher can significantly affect
glucose measurements
Sodium Fluoride
(1000 mg/dL) Decrease glucose by 55% at the 325
mg/dL glucose level, and increase
glucose by 100% at the 20 mg/dL
level
Thiopental
(25 mg/dL)
(13 mg/dL)
Decrease glucose by 30 - 40%
Decrease glucose by >10%