HP Storage Mirroring Software - Manual (Page 147)

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Multiple NICs on the source and target
With any source configuration, additional NICs on the target increases flexibility and control. Secondary target NICs can
assume the traffic from a failed source NIC while normal target traffic can continue to use the primary target NIC. Multiple
sources can be directed to specific NICs.
For example, a single target containing three NICs monitors three source machines located on different subnets. Each source
has one NIC attached to a different subnet. Each source's IP address is configured to be assumed by the target NIC on the
appropriate subnet.
NOTE: When using multiple subnets, the location of the source and target can be critical. If the source and target are
located on different subnets, users cannot access the source machine name and IP address on the target’s
subnet after failover because of routing conflicts. To avoid this situation, keep the source and target on the
same subnet or use a virtual private network.
Source
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Source
Target