Waters Oasis Mixed-Mode Ion-Exchange Cartridges and 96-Well Plates - Manual

CONT ENTS
I. INT RODUCTION
II. SAMPLE P RE-T REATMENT
a. Biological Samples
b. Solid Samples: Soil, Whole foods, Tissue
c. Aqueous Samples: Water, Beverages
d. Non-Aqueous Liquid
III. SOLID-PHASE EX T RACTION P ROC EDURE
FOR BASIC COMPOUNDS USING OASIS
MCX AND ST RONGLY ACIDIC COMPOUNDS
USING OASIS WAX
IV. SOLID-PHASE EX T RACTION P ROC EDURE
FOR ACIDIC COMPOUNDS USING OASIS
MAX AND ST RONGLY BASIC COMPOUNDS
USING OASIS WCX
V. OASIS SORBENT SELECTION AND
P ROTOCOL CHART
VI. OASIS 2X4 MET HOD OPTIMIZED FOR
�ELUTION PLAT E
VII. OASIS PST �ELUTION MET HOD OPTIMIZED
FOR T HERAPEUTIC PEPTIDES BIOANALYSIS
VIII. OASIS 96 W ELL PLAT ES
IX. ORDERING INFORMATION
*The COA, contained in the Oasis Package, displays
results from stringent quality control tests on the batch
of copolymer sorbent and the lot of packed plates.
I. INT RODUCTION
The Oasis ® family of solid-phase extraction (SPE) products
are designed to simplify and improve your sample preparation
by combining the right sorbent chemistry, device format and
methodology. There are five available Oasis Sorbent Chemistries
which are designed to meet all of your sample preparation needs.
They are all built upon a unique, water-wettable Oasis HLB
(Hydrophilic-Lipophilic Balance) copolymer and provide exceptional
results. The sulfonic acid MCX (Mixed-Mode Cation-eXchange),
and quaternary amine MAX (Mixed- Mode Anion-eXchange)
derivatives of Oasis HLB provide dual modes of retention (e.g.
both reversed-phase and ion-exchange retention modes available),
enabling greater cleanup selectivity and sensitivity for basic and
acidic compounds respectively— even if the sorbent in the wells
runs dry. The carboxylic acid WCX (Weak Cation-eXchange) and
the piperazine WAX (Weak Anion eXchange) are also derivatives
of Oasis HLB and provide dual modes of retention. These sorbents
are specifically designed to offer the same benefits and features
as HLB with the ability to retain and release strong bases (e.g.
quaternary amines) and strong acids (e.g. sulfonates) respectively.
All of the five patented Oasis Chemistries are available in several
device formats (e.g. cartridges, 96-well plates, and μElution plates)
to fit your specific needs.
Note: Because the Oasis HLB Sorbent wets as well with water as with
methanol, there is no need to keep the sorbent in the wells wet prior
to sample loading. This benefit not only saves you time but provides
higher and more reproducible recoveries than those obtained on
traditional sorbents.
OASIS MIXED-MODE ION-EXCHANGE CARTRIDGES AND 96-WELL PLATES
[ CARE AND USE MANUAL ]