Waters LCMS Quality Control Reference Materials - Manual

CONT ENTS
I. INT RODUCTION
II. STORAGE & STABILIT Y
III. EXAMPLES OF USING T HE LCMS QC RM
IV. ORDERING INFORMATION
LCMS QC Reference Material
I. INT RODUCTION
The Quality Control Reference Materials (QCRM) portfolio is a
unique collection of standards and mixtures. These products allow
the user to evaluate and benchmark their chromatography system
before analysis of critical material. The products in the portfolio are
all specially formulated based on the expertise of Waters scientist.
The LCMS QCRM is a 9 component mix used to provide a
comprehensive reference standard for use with LC/MS or MS
instrumentation with a wide variety of conditions and methods.
■ ■
The compounds in this mix give a mixture of responses in
ESi (+-) and APCi+
■ ■
Covers a wide range of m/z
■ ■
Optimized concentration to provide a more equal response by
component in ESI+ mode
■ ■
Provides a separation in a range of chromatographic conditions
used to benchmark instrument performance
Table 1. Individual Components in the LCMS QCRM Mix
Component Empirical
Formula
Exact Mass
(as [M+H]+)
Exact Mass
(as [M+H]–)
Concentration
for analysis
(µg/mL)
Acetaminophen C
8
H
9
NO
2
152.0712 150.0555 10
Caffeine C
8
H
10
N
4
O
2
195.0882 1.5
Sulfaguanidine C
7
H
10
N
4
O
2
S 215.0603 213.0446 5
Sulfadimethoxine C
12
H
14
N
4
O
4
S 311.0814 309.0658 1
Val-Tyr-Val C
19
H
29
N
3
O
5
380.2185 378.2029 2.5
Verapamil C
27
H
38
N
2
O
4
455.2910 0.2
Terfenadine C
32
H
41
NO
2
472.3216 0.2
Leucine-Enkephalin C
28
H
37
N
5
O
7
556.2771 554.2615 2.5
Reserpine C
33
H
40
N
2
O
9
609.2812 0.6
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