Waters Neutrals Quality Control Reference Materials - Manual

Neutrals Quality Control Reference Material 1
[ Care and Use ManUal ]
I. IntroductIon
The Quality Control Reference Material (QCRM) portfolio is a unique
collection of standards and mixtures. These products allow the user
to evaluate and benchmark their chromatography system before
analysis of critical material. The products in the portfolio are all
precisely formulated based on the expertise of Waters scientist.
The Neutrals QC Reference Material is a mixture of Acetone, Naph-
thalene and Acenaphthene in 50/50 Acetonitrile and water. It is
precisely formulated to provide system assessment information
quickly and easily. These compounds are well-separated and provide
good peak shape in UV at 254 nm on an analytical chromato-
graphic system in good working order. It can be used on a wide
range of column chemistries and dimensions.
The standards are manufactured in our ISO 9001 ISO 17025 facility.
Each standard is manufactured to ensure optimal reproducibility from
lot-to-lot. A Waters QCRM can be depended on for its’ accuracy.
This removes one variable from your system variability and provides
you the most dependable starting point for your testing.
a. The Purpose of a QCRM:
Waters recommends to benchmark a chromatographic system with
a QCRM prior to system usage when there is confidence that the
system is in good working order. It is recommended to run and save
the initial results and to continue to compare the QCRM results to the
previous benchmark before any critical assay is run, and after any
hardware, column or mobile phase changes.
The QCRM benchmark result will be specific to the performance
of the system it is run on. All chromatographic systems have some
minor level of variability from run to run. Trending of the
benchmark results over time will provide an understanding of system
typical variability. Trending of the same QCRM result on multiple
systems will provide the typical variability of those systems.
Trending of the same QCRM result on systems in laboratories in dif-
Neutrals Quality Control Reference Material
contents
I. IntroductIon
a. The Purpose of a QCRM
b. Determining your QCRM Criteria
c. What Affects your QCRM Result
d. Chromatographic Effects on QCRM: Neutrals
II. storage & stabIlIty
III. usIng the neutrals QcrM
IV. orderIng InforMatIon