ITC VerifyNow System Platelet Reactivity Test - Manual (Page 83)

Page 79 14439.C 03/2013
Appendix - 11
VerifyNow System User Manual | USA
Term Description
Adenosine
diphosphate
ADP. When secreted by activated platelets from storage granules, ADP activates
additional platelets in circulation through two G protein-coupled P2 receptors,
P2Y1 and P2Y12.
Anti-platelet
Platelet inhibition may be induced in response to an anti-platelet agent. Three
classes of potent anti-platelet agents include acetylsalicylic acid (aspirin), P2Y12
inhibitors, and glycoprotein (GP) IIb/IIIa inhibitors.
Arachidonic acid
In an activated platelet, arachidonic acid is converted by cyclo-oxygenase (COX-1)
to prostaglandin G
2
(PGG
2
) and PGH
2
and then to thromboxane A2. Aspirin affects
platelet function by irreversibly inhibiting the cyclo-oxygenase (COX) activity of
prostaglandin (PG) H-synthase, which in turn blocks the metabolism of arachidonic
acid to thromboxane A2 (TXA2).
Aspirin
Acetylsalicylic acid. The primary pharmacological effect of aspirin on platelets is to
decrease the activation of the GP IIb/IIIa receptor and activation of other platelets.
Aspirin reaction
units
Results for the Aspirin test are interpreted based on the extent of platelet
aggregation measured and reported in Aspirin Reaction Units (ARU).
Aggregation,
platelets
The binding of the activated platelet IIb/IIIa receptors to fibrinogen (and vWF)
results in the formation of platelet-platelet and platelet-matrix adhesive interactions
and the formation of a stable, larger platelet aggregate at the site of injury.
Alarm
A type of message that displays after an unexpected event. Alarms are likely
system problems, and in general not serviceable by the customer.
ARU See Aspirin Reaction Units
Test device
There are three types of test devices relating to the appropriate platelet
function test: Aspirin, P2Y12, and GP IIb/IIIa inhibitors (specifically abciximab or
eptifibatide). Each single-use, test device consists of a sample well, staging well,
and four detection wells
Test device port The test device port holds a VerifyNow test device during the test.
Attention
A type of message that displays after an unexpected event. These events may be
simple issues that can be easily addressed by the customer.
Bar code
A series of vertical black and white lines on the white test device package (pouch).
The label stores information about the test type, lot code, expiration, device
calibration factors.
Bar code
Scanner
The bar code scanner scans a bar code on the white test device package, decodes
the bar code, and passes the information to the instrument software.
Baseline
A sample can be drawn prior to drug administration, and it can be used as a
baseline reading for determining percent inhibition (for IIb/IIIa test).
Cleaning device
A single use, disposable plastic component with an adhesive strip. The cleaning
device is used to remove debris from a pneumatic port connection inside the test
device port.
Clopidogrel Clopidogrel (trade name Plavix ® - clopidogrel bisulfate) is a potent oral antiplatelet
agent used in the treatment of coronary artery disease, peripheral vascular
disease, and cerebrovascular disease. As a thienopyridine, its mechanism of
action is inhibition of the P2Y12 receptor.
Cover A plastic door on the instrument that shields the test device port from ambient light.
Date extension When Accumetrics issues a date extension notification for a specific lot of test
devices, these devices can be used after the original expiration date.