BUCHI Inert Loop B-295 - Manual (Page 7)

2 Safety
7 B-290 Operation Manual, Version I
2 Safety
This chapter highlights out the safety concept of the instrument and contains general rules of behavior
and warnings from direct and indirect hazards concerning the use of the product.
For the users safety, all safety instructions and safety messages in the individual sections shall
be strictly observed and followed. Therefore, the manual must always be available to all persons
performing any tasks described herein.
2 .1 User qualification
The instrument is designed and built in accordance with state-of-the-art technology. Nevertheless, risks
to users, property, and the environment can arise when the instrument is used carelessly or improperly.
The manufacturer has determined residual dangers emanating from the instrument
• if the instrument is operated by insufficiently trained personnel without supervision.
• if the instrument is not operated according to its proper use.
Appropriate warnings in this manual serve to make the user alert to these residual hazards.
Personnel without this training or persons who are currently being trained require careful instruction.
The present Operation Manual serves as the basis for this.
2 .2 Proper use
The Mini Spray Dryer B-290 has been designed and built as laboratory instrument and for batch
production. It serves to spray-dry aqueous solutions or suspensions in one operating process.
In combination with the Inert Loop B-295, it is possible to work with organic solvents in “closed
mode”. Processing in “closed mode” requires N
2
or CO
2
as an inert gas.
The output particle size of the Mini Spray Dryer B-290 is between 2–25 µm. Thus, the instrument is
suited to generate particles in the inhalable size range from a solution of suspension.
• If the instrument is used with potentially toxic or hazardous substances in ‘open mode’, it has
to be installed inside a closed fume hood or glove box. In such cases, the complete processing
and system handling has to be performed within the ventilated box to avoid toxication and other
hazardous situations to the user and the environment.
• Spray drying of corrosive samples require handling in a closed fume hood. An acid proof system in
open loop is a variant of the Mini Spray Dryer B-290.
• In any case, all exhausts leaving the exhaust gas tubing have to be lead away instantly by a ventila-
tion system, to remove possibly hazardous substances and fumes from the working area. The
ventilation system has to be equipped with safety measures such as outlet filters to avoid contami-
nation of the environmen.
• Operation and handling can require additional personal protective equipment. Operate the instru-
ment with respect to standard laboratory safety rules (i.e. as stated in the latest version of the WHO
“Laboratory biosafety manual”) at all times.
• If the Mini Spray Dryer B-290 is used in combination with other instruments (e.g. Chiller) all related
manuals are to be fully observed.
• Electrostatic charges are to be arrested from both the product collection vessel and the cyclone via
the standard grounding cable if the cyclone is equipped with a grounding socket.
• If the instrument is used for food, pharma and cosmetic products additional cleaning measures
(primary cleaning and in place disinfection) are required (see chapter 5.7).