BUCHI Inert Loop B-295 - Manual (Page 46)

5 Putting into operation
46 B-290 Operation Manual, Version I
5 .16 Additional cleaning measures for food, pharma and cosmetic applications
For food, pharma and cosmetic products additional measures are required during the whole spray
drying process to establish the necessary hygienic level. Any risk of infection, diseases or contagion
must be excluded!
To disinfect the Mini Spray Dryer B-290 in place the glass does not have to be sterilized separately.
The device must not be opened before the experiment after the SIP (Sterilization In Place)
process .
NOTE
It is highly recommended to use a new set of tubes and filters to further reduce the risk of contami-
nation between two spray drying processes. The filters must either be decontaminated and sterile or
disinfected prior to use.
5 .16 .1 Primary cleaning
All glass parts can be manually rinsed with a disinfection medium (e.g. ethanol) under hygienic condi-
tions. Primary cleaning can be done mechanically e.g. by means of a disinfected brush. However, the
primary cleaning must effectively remove all residua of previous operations!
Because of the bandwith of possible materials to be processed with the Mini Spray Dryer B-290 it
is not possible to recommend a general purpose detergent. Contact your local hygienic specialist or
BUCHI representative for a suitable detergent for your specific application! NOTE the material list in
section 3.3.
Clean all used hoses with isopropanol 70 % and keep them at 110 °C for 30 minutes.
Sealings in contact with the product can be cleaned and disinfected in an ultrasonic bath with a corre-
sponding disinfection medium. At reinstallation, mind hygienic handling!
NOTE
Do not bring the seals in contact with lubricants or other harmful substances!
After cleaning, the system must be assembled to run the in place disinfection process.