Nikon D500 - Manual (Page 150)

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ISO Sensitivity
The higher the ISO sensitivity, the less light needed to make an
exposure, allowing faster shutter speeds or smaller apertures, but the
more likely the image is to be affected by noise (randomly-spaced
bright pixels, fog, or lines). Noise is particularly likely at settings
between Hi 0.3 and Hi 5.
A Hi 0.3–Hi 5
The settings Hi 0.3 through Hi 5 correspond to ISO sensitivities 0.3–
5 EV over ISO 51200 (ISO 64000–1640000 equivalent).
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Lo 0.3–Lo 1
The settings Lo 0.3 through Lo 1 correspond to ISO sensitivities 0.3–
1 EV below ISO 100 (ISO 80–50 equivalent). Use for larger apertures
when lighting is bright. Contrast is slightly higher than normal; in most
cases, ISO sensitivities of ISO 100 or above are recommended.
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See Also
For information on choosing the ISO sensitivity step size, see Custom
Setting b1 (ISO sensitivity step value;
0 294). See Custom Setting d3
(ISO display; 0 297) for information on displaying ISO sensitivity in
the control panel and viewfinder. For information on using the High
ISO NR options in the photo and movie shooting menus to reduce
noise at high ISO sensitivities, see pages 286 (photos) and 290
(movies).