KD Scientific Adagio Control Software for Legato Series Manual - Manual (Page 35)

Adagio User Manual © 2010 KD Scientific
5619-001 Rev B
35
The number of doses, dose value and lag time fields are available only if
the “Multiple Doses” option is selected. This means that a step sequence
is to be built from a known dose and concentration.
The duration value field is available only if the “Single Dose” option is
selected. This means that a single step is to be built from a known
concentration and duration.
All numerical values (except the doses count, which must be an integer
value) can be entered with up to 4 decimals making use of the decimal
symbol currently configured in the Microsoft® Windows® regional
settings.
The step sequence is generated from the data entered in the wizard and
depends mainly on the option selected:
• Multiple Doses: a step sequence is built to repeatedly infuse /
withdraw a volume of :
V (ml) = ([Dose to apply (mg/kg)] * [Subject weight (kg)]) /
[Concentration (mg/ml)]
as many times as [Number of doses] states with a break time of [Lag
time (min]] between two consecutive doses.
That means that one step is added for each dose with the following
parameters:
o Duration (min) = V (ml) / [Flow rate (ml/min)]
o Start flow (ml/min) = [Flow rate (ml/min)]
o End flow (ml/min) = Start flow
o Step linkage property = Not linked
Each of these steps is then followed by the corresponding lag step
with the following parameters:
o Duration (min) = [Lag time (min)]
o Start flow (ml/min) = 0
o End flow (ml/min) = 0
o Step linkage property = Not linked