Brother 4000CN - Manual (Page 27)

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When you remove the transfer roll cartridge from the printer because the waste
toner collection box is full, do not attempt to empty the waste toner box and
reuse the cartridge, as toner may spill inside the printer and cause damage.
Loose toner can spill inside the printer and deteriorate print quality.
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Do not tilt or shake the print head cartridges or transfer roll cartridges when
removing them temporarily. Loose toner can spill inside the printer and
deteriorate print quality.