Metrohm NIRS XDS MasterLab Analyzer - Manual (Page 43)

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of the Universal Tablet Tray. (Remember that spectral intensity changes somewhat with detector
height.)
Bore sizes (diameter), for tablet sizes A-D, are as follows:
Tablet
Size Small Tablet
Bore Bore Depth,
Small Tablet Large Tablet
Bore Bore Depth,
Large Tablet Through
Bore
A .270” / 6.85 mm
.095” / 2.41
mm .313” / 7.95
mm .062” / 1.57
mm .170” / 4.32
mm
B .360” / 9.14 mm
.095” / 2.41
mm .375” / 9.53
mm .062” / 1.57
mm .250” / 6.35
mm
C
.412” / 10.46
mm .095” / 2.41
mm .446” / 11.33
mm .062” / 1.57
mm .313” / 7.95
mm
D
.477” / 12.12
mm .095” / 2.41
mm .562” / 14.27
mm .062” / 1.57
mm .375” / 9.53
mm
If the nominal tablet diameter is known, use this chart to select the tablet hole type and bore
diameter using this table:
NOTE 1: Nominal tablet diameter may vary based upon pressing conditions, storage, or other
factors. It is helpful to consult the production print for a tablet, to determine its range of finished
diameters, when choosing a tablet position in the Universal Tablet Tray.
NOTE 2: Tablets should not be handled without suitable protection. There are two primary
reasons for this. One is a safety concern, in that some of the tablet active ingredient could be
absorbed through the skin, or transferred to the eyes or another sensitive area of the human
body. The second reason is that skin oils will affect the NIR spectrum of the tablet, and may be
misleading.
NOTE 3: Intagliation, or embossing on the tablet surface, should be positioned consistently for
best results. As a rule, intagliation should be “up” in the holder. This position allows the NIR beam
to enter the tablet cleanly (with less scattering on the lower side) which theoretically provides
more energy to the detector.