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Controls, And samples – Bio-Rad Human MMP and TIMP Assays User Manual

Page 26

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Table 13. Bead regions for the human inflammation panel.

Target

Bead

Region

Target

Bead

Region

Target

Bead

Region

APRIL/TNFSF13

42

IL-11

39

LIGHT/TNFSF14

51

BAFF/TNFSF13B

37

IL-12 (p40)

28

MMP-1

43

sCD30/TNFRSF8

53

IL-12 (p70)

75

MMP-2

26

sCD163

46

IL-19

29

MMP-3

45

Chitinase 3-like 1

72

IL-20

30

Osteocalcin

65

gp130/sIL-6Rß

14

IL-22

18

Osteopontin (OPN)

77

IFN-

a2

20

IL-26

22

Pentraxin-3

48

IFN-ß

44

IL-27 (p28)

13

sTNF-R1

73

IFN-

g

21

IL-28A/IFN-

l2

66

sTNF-R2

67

IL-2

38

IL-29/IFN-

l1

33

TSLP

52

IL-6R

a

19

IL-32

35

TWEAK/TNFSF12

62

IL-8

54

IL-34

15

IL-10

56

IL-35

34

Note: Do not use preset panels found in Bio-Plex Manager software
version 5.0 or earlier, as the bead regions are not up to date.

3. Click Format Plate and format the plate according to the plate layout

created in section 1 (Plan Plate Layout). To modify the plate layout,
follow the steps below (see Figure 4).

a. Select

the

Plate Formatting tab.

b. Select the standards icon

S

and drag the cursor over all the

wells that contain standards. Repeat this process for

Blanks

B

, Controls

C

, and Samples

X

. Note that

Bio-Plex Manager automatically subtracts the blank MFI
value from all other assay wells.

4. Click Enter Standards Info in the Protocol Settings bar.
a. Enter the highest concentration of each analyte in the top row

(labeled S1) of the table. S1 concentration information is included
with each vial of standards.