JLCooper eBOX GPI8 - Manual (Page 43)

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In Programming mode, only one button (the one being
programmed) can be active at once. In Live mode, any button can
be active.
When the eBOX GPI8 Control Center is the front application in
Live mode, you determine which keyset is active using the
Keysets menu. If the eBOX GPI8 Control Center is in the
background, or not running at all, the eBOX GPI8 driver
automatically switches keysets based on the front application. If
there is no keyset for the frontmost application, then the driver uses
the Global keyset.
When the eBOX GPI8 Control Center is not the front application,
you can use the keyboard triggers you defined in Programming
Mode to initiate the actions you assigned to the various buttons.
If the eBOX GPI8 Control Center is visible in the background, and
in Live Mode, then its indicators will still display the states of the
GPI Input and Output Pins.