Metrohm 824 Easy Sample Changer - Manual (Page 42)

5.2 Care / Maintenance
36
824 Easy Sample Changer, GLP validation
6 GLP validation
Each Metrohm instrument undergoes a rigorous quality control process
before dispatch.
GLP (Good Laboratory Practice) requires, among other things, that
the precision and correctness of analytical instruments is checked at
regular intervals by using SOPs (Standard Operating Procedure, SOP).
As this instrument is not an analytical instrument as such, we recom-
mend the user to include the 824 Easy Sample Changer as part of an
analytical system in its all-embracing validation.
If the sample changer is primarily used for titrations then the validation
of the titrator is best carried out by using the sample changer. In this
way any interference (e.g. carryover of titrant or sample solution), which
could influence the results obtained, in included within the framework of
the evaluation of the complete titration system.
Checking the electronic and mechanical assemblies of Metrohm in-
struments can and should be undertaken within the framework of regu-
lar servicing by Metrohm technicians. All Metrohm instruments are
equipped with start-up check routines which check that the relevant as-
semblies are functioning perfectly when the instrument is switched on. If
no error message appears it can be assumed that the instrument is
functioning properly. Metrohm also supplies the instruments with built-in
diagnosis programs which allow the service technicians to check the
functioning of particular assemblies should faults or malfunctions occur
and to localize them.
Recommended literature
• Metrohm booklets "Quality management with Metrohm"; detailed in-
formation about the principles and methods of Good Laboratory
Practice
• Metrohm Application Bulletin 252/1 "Validation of Metrohm titrators
according to GLP/ISO 9001"