Penn-Century DP-4_4M - Manual (Page 5)

5
Description of Models
DRY POWDER INSUFFLATOR™ - MODEL DP-4
Dry Powder Insufflator™ Model DP-4-R for Rat
is designed for intratracheal or intranasal use in Rat.
The delivery tube is made of stainless steel that
extends 2” after a 120-degree bend. The Model DP-4
is intended to be loaded with one dose (of 1-5 mg)
per administration. It operates with a 3ml air syringe
provided, or, if desired, a Penn-Century Air Pump.
The air pulse is determined by the tidal volume of the
animal to be used. For use in Rat, air pulses should
not exceed 2 ml per pulse.
Dry Powder Insufflator™ Model DP-4-GP for Guinea Pig is designed for intratracheal or intranasal use in
Rat. The delivery tube is made of stainless steel that extends 3” after a 120-degree bend. The Model DP-4 is
intended to be loaded with one dose (of 1-5 mg) per administration. It operates with a 3 ml air syringe provided,
or, if desired, a Penn-Century Air Pump. The air pulse is determined by the tidal volume of the animal to be
used. For use in Guinea Pig, air pulses should not exceed 3 ml per pulse.
Dry Powder Insufflator™ Model DP-4-C (Custom)
Custom devices can be made with delivery tubes that are sized for intratracheal use in larger animals. These
custom-made delivery tubes can be made of soft, flexible plastic tubing that can be inserted into the trachea via a
bronchoscope, or made of rigid stainless steel, to be inserted directly, or via an endotracheal tube.
DRY POWDER INSUFFLATOR™ - MODEL DP-4M FOR MOUSE
The Dry Powder Insufflator™ Model DP-4M for Mouse has a unique design and valve system that is
not the same as the Model DP-4. It is specifically designed for intratracheal or intranasal use in Mouse. The
device is made of chemically resistant PEEK™ parts, silicone valves, and a stainless steel delivery tube. It has a
shorter, more narrow diameter delivery tube than the DP-4 and is suitable for intratracheal powder administration
in mice that extends 1.25” at the tip (after a 120-degree bend). The DP-4M valve system is designed to release
the powder using a far smaller volume of air than is required for powder release with the Model DP-4. It is
designed for precise administration of one dose at a time in a dose volume of 1-2 mg. It is not designed to be
filled with a large volume of powder to dose multiple animals.
The Model DP-4M is best used with Penn-
Century Air Pump.
The Model DP-4M is designed to be operated with a
Penn-Century Air Pump – Model AP-1, which
permits precise, rapid, repeatable administration of
pulses of air at 200µl per pulse. The Air Pump **
minimizes hand motion, which is critical when
working in a smaller animal, and eliminates the
need to remove and reinsert the tip of the DP-4M to
apply a second or third pulse of air, if needed. The
size of the air pulse is determined by the tidal
volume of the animal to be used. For use in Mouse,
air pulses should not exceed of 200µl per pulse.
**NOTE: The Air Pump Model AP-1 has been discontinued due to changes from our suppliers. We are developing a new, hand-held Air Pump
Model AP-2 for rapid applications of precise volumes of air for use with our Dry Powder Insufflator™ Model DP-4 or Mode DP-4M. The new
Air Pump will be available after development and testing to assure t meets our quality standards. Contact us for updates.