Penn-Century DP-4_4M - Manual (Page 4)

4
Correct placement in the trachea is essential.
For intratracheal use, the placement of the very tip of the delivery tube is critical for obtaining the best results. In
prior published studies, optimal lung deposition from Penn-Century intratracheal aerosol devices is obtained when
the very tip is carefully positioned in the trachea so that the very tip is near to but not touching the carina (first
bifurcation) of the anesthetized animal The device exerts a slight insufflating effect, and permits the user to
administer a precisely measured dose of dry powder deep into the lung.
Cautions for intratracheal use in the animal.
Use of all Penn-Century devices for intratracheal applications is
essentially a form of intubation. Familiarity with intubation and anesthetized animal prep is a prerequisite for use
of the devices. The user must insert the tip of the device gently down the trachea of the anesthetized animal,
near to but not touching the carina. When using the any Penn-Century intratracheal aerosol device – whether
liquid or dry powder, the user must push the plunger of the syringe fast and with force to aerosolize the liquid
inside. For optimal lung deposition, the tip of the delivery tube must be positioned near to, but not touching the
carina. Therefore, the user must exercise care and attention to
minimize any forward motion of the hand
while pushing quickly and firmly on the plunger, to prevent trauma or injury to the animal.
Tip of device
Trachea
Aerosol
Carina
Intratracheal use of Penn-Century
devices. For best results, position
the tip of the device near to - but
not touching the carina, or first
bifurcation