Multichannel Systems MEA2100-System Manual - Manual (Page 52)

MEA2100-System Manual
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6.7
Missing Spikes or Strange Signal Behavior
MEAs wear out after multiple uses or over a longer time of use, for example for long-term
cultures. The insulation layer gets thin over time. This is considered a normal behavior.
Possible causes:
? The insulation layer is too thin. As a result, the MEA gets the behavior of a low pass filter. This
means, that the signal frequency may be shifted to a lower frequency, and spikes are missing.
Optically control the MEA with a microscope. If concentric colored rings (Newton rings) are visible
(due to light interference), the insulation layer is too thin and you should use a fresh MEA.
? The insulation layer has been abraded and is missing in parts. This will result in a short circuit
between the electrodes or tracks and the bath. You will still see signals, but as an unspecific smear
over the complete array.
Use a fresh MEA.