Bio-Rad Nuvia™ cPrime™ Media User Manual
Page 5

2
Section 2
Technical Description
Table 1. Nuvia™ cPrime™ media technical description.
Functional group
Hydrophobic cation exchanger
Base matrix composition
Macroporous highly crosslinked
hydrophilic polymer
Particle size
70 µm ± 10 µm
Dynamic binding capacity*
≥ 40 mg/ml
Ligand density
55–75 µeq/ml
Recommended linear flow
rate range
50–600 cm/hr
Pressure vs. flow
performance**
Under 2 bar @ a flow rate of 600
cm/hr
pH stability
2–14 short term
3–13 long term
Chemical stability
1.0 N NaOH, 1.0 N HCl, 25%
HOAc, 8 M Urea, 6 M Gu-HCl,
6 M KSCN, 3 M NaCl, 1% Triton
X-100, 2% SDS + 0.25 M NaCl,
20% ethanol, 70% ethanol, 30%
isopropanol
Shipping solution
20% ethanol
Storage conditions
20% ethanol
Shelf life***
5 yrs
* at 10% breakthrough hIgG.
** 20 cm X 20 cm packed bed (1.17 compression factor).
*** Stored at room temperature in 20% ethanol under accelarated
conditions.
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