Asus Rampage III Gene - Manual (Page 33)

DO NOT overtighten the screws! Doing so can damage the motherboard.
2.2.3 Placement direction
When installing the motherboard, ensure that you place it into the chassis in
the correct orientation. The edge with external ports goes to the rear part of the
chassis as indicated in the image below.
2.2.4 Screw holes
Place eight (8) screws into the holes indicated by circles to secure the motherboard
to the chassis.
Place this side towards
the rear of the chassis
ROG Rampage III GENE 2-9