Asus P5E-VM SE - Manual (Page 21)

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1.5 Motherboard overview
Before you install the motherboard, study the configuration of your chassis to
ensure that the motherboard fits into it.
Make sure to unplug the power cord before installing or removing the
motherboard. Failure to do so can cause you physical injury and damage
motherboard components.
1.5.1 Placement direction
When installing the motherboard, make sure that you place it into the chassis in
the correct orientation. The edge with external ports goes to the rear part of the
chassis as indicated in the image below.
1.5.2 Screw holes
Place eight (8) screws into the holes indicated by circles to secure the motherboard
to the chassis.
Do not overtighten the screws! Doing so can damage the motherboard.
Place this side towards
the rear of the chassis