Cerebral injury, Cerebral injury 9 – ZOLL Thermogard XP IVTM Physician Manual User Manual
Page 10
ZOLL IVTM™ System
Physicians' Manual
600248-001 Rev 3
9
Exogenous pyrogens are polypeptides of origin external to endogenous pyrogens but
of similar action.
Cerebral Injury
Sustained changes in the thermoregulatory set-point are observed with irritation or
compression (tumor) of the hypothalamus. In addition, intra-cerebral release of
endogenous pyrogens (cerebral inflammation) can have the same effect. The
hypothalamus is exposed to cerebrospinal fluid as well as to blood, so it can be
subject to the action of CSF-borne pyrogens [2].
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