MEGUIAR'S G37 - Manual (Page 26)

G123, PlastX (22-121A): G12306, G12310
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one
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one
In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Solvent naphtha (petroleum), medium aliphatic Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Solvent naphtha (petroleum), medium aliphatic Inhalation Human
and
animal Some positive data exist, but the data are not
sufficient for classification
Aluminium oxide Inhalation Rat Not carcinogenic
White mineral oil (petroleum) Dermal Mouse Not carcinogenic
White mineral oil (petroleum) Inhalation Multiple
animal
species Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Solvent naphtha (petroleum), medium
aliphatic Inhalation Not toxic to development Rat NOAEL 2.4
mg/l during
organogenesis
White mineral oil (petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day during
gestation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Solvent naphtha
(petroleum), medium
aliphatic Inhalation central nervous
system depression May cause drowsiness or
dizziness Human
and
animal NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic Inhalation nervous system Some positive data exist, but the
data are not sufficient for
classification Dog NOAEL 6.5
mg/l 4 hours
Mixture of 5-chloro-2-
methyl-2H-isothiazol-3-
one and 2-methyl-2H-
isothiazol-3-one Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification similar
health
hazards NOAEL Not
available