MEGUIAR'S G37 - Manual (Page 11)

G171, Headlight Protectant (XP4-137A): G17104
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Bis(1,2,2,6,6-pentamethyl-4-piperidyl)sebacate Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Processed oil Human Some positive data exist, but the data are not
sufficient for classification
Bis(1,2,2,6,6-pentamethyl-4-piperidyl)sebacate Guinea
pig Sensitising
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Distillates (petroleum), hydrotreated middle In Vitro Some positive data exist, but the data are not
sufficient for classification
Processed oil In Vitro Not mutagenic
Processed oil In vivo Not mutagenic
Bis(1,2,2,6,6-pentamethyl-4-piperidyl)sebacate In Vitro Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Distillates (petroleum), hydrotreated middle Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Processed oil Ingestion Not toxic to female reproduction Rat NOAEL
4,800
mg/kg/day 13 weeks
Processed oil Ingestion Not toxic to male reproduction Rat NOAEL
4,800
mg/kg/day 13 weeks
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H- Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis