MEGUIAR'S G37 - Manual (Page 25)

G123, PlastX (22-121A): G12306, G12310
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Aluminium oxide Dermal LD50 estimated to be > 5,000 mg/kg
White mineral oil (petroleum) Dermal Rabbit LD50 > 2,000 mg/kg
Aluminium oxide Inhalation-
Dust/Mist
(4 hours) Rat LC50 > 2.3 mg/l
Aluminium oxide Ingestion Rat LD50 > 5,000 mg/kg
White mineral oil (petroleum) Ingestion Rat LD50 > 5,000 mg/kg
Siloxanes and silicones, di-Me Dermal Rabbit LD50 > 19,400 mg/kg
Siloxanes and silicones, di-Me Ingestion Rat LD50 > 17,000 mg/kg
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Rabbit LD50 87 mg/kg
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Inhalation-
Dust/Mist
(4 hours) Rat LC50 0.33 mg/l
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat LD50 40 mg/kg
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
Solvent naphtha (petroleum), medium aliphatic Rabbit Irritant
Aluminium oxide Rabbit No significant irritation
White mineral oil (petroleum) Rabbit No significant irritation
Siloxanes and silicones, di-Me Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
Solvent naphtha (petroleum), medium aliphatic Rabbit No significant irritation
Aluminium oxide Rabbit No significant irritation
White mineral oil (petroleum) Rabbit Mild irritant
Siloxanes and silicones, di-Me Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Solvent naphtha (petroleum), medium aliphatic Guinea
pig Not sensitizing
White mineral oil (petroleum) Guinea
pig Not sensitizing
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Solvent naphtha (petroleum), medium aliphatic In vivo Not mutagenic
Solvent naphtha (petroleum), medium aliphatic In Vitro Some positive data exist, but the data are not
sufficient for classification
Aluminium oxide In Vitro Not mutagenic
White mineral oil (petroleum) In Vitro Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3- In vivo Not mutagenic