MEGUIAR'S M10 - Manual (Page 8)

M10, Plastic Polish (original formulation): M1008
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Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
White mineral oil (petroleum) Dermal Mouse Not carcinogenic
White mineral oil (petroleum) Inhalation Multiple
animal
species Not carcinogenic
Distillates (petroleum), hydrotreated light Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Glycerin Ingestion Mouse Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
White mineral oil (petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day during
gestation
Glycerin Ingestion Not toxic to female reproduction Rat NOAEL
2,000
mg/kg/day 2 generation
Glycerin Ingestion Not toxic to male reproduction Rat NOAEL
2,000
mg/kg/day 2 generation
Glycerin Ingestion Not toxic to development Rat NOAEL
2,000
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Distillates (petroleum),
hydrotreated light Inhalation central nervous
system depression May cause drowsiness or
dizziness NOAEL Not
available
Distillates (petroleum),
hydrotreated light Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification NOAEL Not
available
Mixture of 5-chloro-2-
methyl-2H-isothiazol-3-
one and 2-methyl-2H- Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification similar
health
hazards NOAEL Not
available