MEGUIAR'S D163 - Manual (Page 7)

D163, Tyre & Trim Detailer (24-47A): D16332
__________________________________________________________________________________________
Page: 7 of 14
2H-isothiazol-3-one Dust/Mist
(4 hours)
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat LD50 40 mg/kg
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
Distillates (petroleum), hydrotreated light Rabbit Mild irritant
Triethanolamine Rabbit Minimal irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
Distillates (petroleum), hydrotreated light Rabbit Mild irritant
Triethanolamine Rabbit Mild irritant
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Distillates (petroleum), hydrotreated light Guinea
pig Not sensitizing
Triethanolamine Human Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Distillates (petroleum), hydrotreated light In Vitro Not mutagenic
Triethanolamine In Vitro Not mutagenic
Triethanolamine In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Distillates (petroleum), hydrotreated light Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Triethanolamine Dermal Multiple
animal
species Not carcinogenic
Triethanolamine Ingestion Mouse Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic