MEGUIAR'S D300 - Manual (Page 10)

D300, DA Microfiber Correction Compound (21-49D): D30001, D30016, D30032
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Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Solvent naphtha (petroleum), medium
aliphatic Inhalation Not toxic to development Rat NOAEL 2.4
mg/l during
organogenesis
White mineral oil (petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White mineral oil (petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day during
gestation
Glycerin Ingestion Not toxic to female reproduction Rat NOAEL
2,000
mg/kg/day 2 generation
Glycerin Ingestion Not toxic to male reproduction Rat NOAEL
2,000
mg/kg/day 2 generation
Glycerin Ingestion Not toxic to development Rat NOAEL
2,000
mg/kg/day 2 generation
Triethanolamine Ingestion Not toxic to development Mouse NOAEL
1,125
mg/kg/day during
organogenesis
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Solvent naphtha
(petroleum), medium
aliphatic Inhalation central nervous
system depression May cause drowsiness or
dizziness Human
and
animal NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification NOAEL Not
available
Solvent naphtha
(petroleum), medium
aliphatic Inhalation nervous system Some positive data exist, but the
data are not sufficient for
classification Dog NOAEL 6.5
mg/l 4 hours
Mixture of 5-chloro-2-
methyl-2H-isothiazol-3-
one and 2-methyl-2H-
isothiazol-3-one Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification similar
health
hazards NOAEL Not
available
Specific Target Organ Toxicity - repeated exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Aluminium Oxide Inhalation pneumoconiosis |
pulmonary fibrosis Some positive data exist, but the
data are not sufficient for
classification Human NOAEL Not
available occupational
exposure
Solvent naphtha
(petroleum), medium Inhalation nervous system Some positive data exist, but the
data are not sufficient for Rat LOAEL 4.6
mg/l 6 months