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MEGUIAR'S D300 User Manual

Page 10

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D300, DA Microfiber Correction Compound (21-49D): D30001, D30016, D30032

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Page: 10 of 18

Reproductive Toxicity

Reproductive and/or Developmental Effects

Name

Route

Value

Species

Test result

Exposure
Duration

Solvent naphtha (petroleum), medium
aliphatic

Inhalation

Not toxic to development

Rat

NOAEL 2.4
mg/l

during

organogenesis

White mineral oil (petroleum)

Ingestion

Not toxic to female reproduction

Rat

NOAEL
4,350
mg/kg/day

13 weeks

White mineral oil (petroleum)

Ingestion

Not toxic to male reproduction

Rat

NOAEL
4,350
mg/kg/day

13 weeks

White mineral oil (petroleum)

Ingestion

Not toxic to development

Rat

NOAEL
4,350
mg/kg/day

during

gestation

Glycerin

Ingestion

Not toxic to female reproduction

Rat

NOAEL
2,000
mg/kg/day

2 generation

Glycerin

Ingestion

Not toxic to male reproduction

Rat

NOAEL
2,000
mg/kg/day

2 generation

Glycerin

Ingestion

Not toxic to development

Rat

NOAEL
2,000
mg/kg/day

2 generation

Triethanolamine

Ingestion

Not toxic to development

Mouse

NOAEL
1,125
mg/kg/day

during

organogenesis

Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one

Ingestion

Not toxic to female reproduction

Rat

NOAEL 10
mg/kg/day

2 generation

Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one

Ingestion

Not toxic to male reproduction

Rat

NOAEL 10
mg/kg/day

2 generation

Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one

Ingestion

Not toxic to development

Rat

NOAEL 15
mg/kg/day

during

organogenesis

Target Organ(s)

Specific Target Organ Toxicity - single exposure

Name

Route

Target Organ(s)

Value

Species

Test result

Exposure
Duration

Solvent naphtha
(petroleum), medium
aliphatic

Inhalation

central nervous
system depression

May cause drowsiness or
dizziness

Human
and
animal

NOAEL Not
available

Solvent naphtha
(petroleum), medium
aliphatic

Inhalation

respiratory irritation

Some positive data exist, but the
data are not sufficient for
classification

NOAEL Not
available

Solvent naphtha
(petroleum), medium
aliphatic

Inhalation

nervous system

Some positive data exist, but the
data are not sufficient for
classification

Dog

NOAEL 6.5
mg/l

4 hours

Mixture of 5-chloro-2-
methyl-2H-isothiazol-3-
one and 2-methyl-2H-
isothiazol-3-one

Inhalation

respiratory irritation

Some positive data exist, but the
data are not sufficient for
classification

similar
health
hazards

NOAEL Not
available

Specific Target Organ Toxicity - repeated exposure

Name

Route

Target Organ(s)

Value

Species

Test result

Exposure
Duration

Aluminium Oxide

Inhalation

pneumoconiosis |
pulmonary fibrosis

Some positive data exist, but the
data are not sufficient for
classification

Human

NOAEL Not
available

occupational
exposure

Solvent naphtha
(petroleum), medium

Inhalation

nervous system

Some positive data exist, but the
data are not sufficient for

Rat

LOAEL 4.6
mg/l

6 months