MEGUIAR'S M40 - Manual (Page 7)

M40, Vinyl/Rubber Cleaner and Protectant (19-191E): M4001, M4005, M4016
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2H-isothiazol-3-one
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
Propane-1,2-diol Rabbit No significant irritation
Alcohols, C11-14-iso-, C13-rich, ethoxylated Rabbit Mild irritant
Trisodium Phosphate Rabbit Irritant
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
Propane-1,2-diol Rabbit No significant irritation
Alcohols, C11-14-iso-, C13-rich, ethoxylated Rabbit Corrosive
Trisodium Phosphate Rabbit Corrosive
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Propane-1,2-diol Human Some positive data exist, but the data are not
sufficient for classification
Alcohols, C11-14-iso-, C13-rich, ethoxylated Human Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Propane-1,2-diol In Vitro Not mutagenic
Propane-1,2-diol In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Propane-1,2-diol Dermal Mouse Not carcinogenic
Propane-1,2-diol Ingestion Multiple
animal
species Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity