MEGUIAR'S M63 - Manual (Page 9)

M63, Flagship Marine Liquid Wax (21-105A): M6316, M6332, M6301
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Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Inhalation-
Dust/Mist
(4 hours) Rat LC50 0.33 mg/l
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat LD50 40 mg/kg
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
Naphtha (petroleum), hydrotreated heavy Rabbit Irritant
Distillates (petroleum), hydrotreated light Rabbit Mild irritant
Siloxanes and silicones, di-Me Rabbit No significant irritation
Stoddard solvent Rabbit Irritant
White Mineral Oil (Petroleum) Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
Naphtha (petroleum), hydrotreated heavy Rabbit No significant irritation
Distillates (petroleum), hydrotreated light Rabbit Mild irritant
Siloxanes and silicones, di-Me Rabbit No significant irritation
Stoddard solvent Rabbit No significant irritation
White Mineral Oil (Petroleum) Rabbit Mild irritant
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Naphtha (petroleum), hydrotreated heavy Guinea
pig Not sensitizing
Distillates (petroleum), hydrotreated light Guinea
pig Not sensitizing
Stoddard solvent Guinea
pig Not sensitizing
White Mineral Oil (Petroleum) Guinea
pig Not sensitizing
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
Naphtha (petroleum), hydrotreated heavy In vivo Not mutagenic
Naphtha (petroleum), hydrotreated heavy In Vitro Some positive data exist, but the data are not
sufficient for classification
Distillates (petroleum), hydrotreated light In Vitro Not mutagenic
Stoddard solvent In vivo Not mutagenic
Stoddard solvent In Vitro Some positive data exist, but the data are not
sufficient for classification
White Mineral Oil (Petroleum) In Vitro Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic