MEGUIAR'S M63 - Manual (Page 10)

M63, Flagship Marine Liquid Wax (21-105A): M6316, M6332, M6301
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Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Naphtha (petroleum), hydrotreated heavy Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Naphtha (petroleum), hydrotreated heavy Inhalation Human
and
animal Some positive data exist, but the data are not
sufficient for classification
Distillates (petroleum), hydrotreated light Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Stoddard solvent Dermal Mouse Some positive data exist, but the data are not
sufficient for classification
Stoddard solvent Inhalation Human
and
animal Some positive data exist, but the data are not
sufficient for classification
White Mineral Oil (Petroleum) Dermal Mouse Not carcinogenic
White Mineral Oil (Petroleum) Inhalation Multiple
animal
species Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
Naphtha (petroleum), hydrotreated heavy Inhalation Not toxic to development Rat NOAEL 2.4
mg/l during
organogenesis
Stoddard solvent Inhalation Not toxic to development Rat NOAEL 2.4
mg/l during
organogenesis
White Mineral Oil (Petroleum) Ingestion Not toxic to female reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White Mineral Oil (Petroleum) Ingestion Not toxic to male reproduction Rat NOAEL
4,350
mg/kg/day 13 weeks
White Mineral Oil (Petroleum) Ingestion Not toxic to development Rat NOAEL
4,350
mg/kg/day during
gestation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to female reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to male reproduction Rat NOAEL 10
mg/kg/day 2 generation
Mixture of 5-chloro-2-methyl-2H-
isothiazol-3-one and 2-methyl-2H-
isothiazol-3-one Ingestion Not toxic to development Rat NOAEL 15
mg/kg/day during
organogenesis
Target Organ(s)
Specific Target Organ Toxicity - single exposure
Name Route Target Organ(s) Value Species Test result Exposure
Duration
Naphtha (petroleum),
hydrotreated heavy Inhalation central nervous
system depression May cause drowsiness or
dizziness Human
and
animal NOAEL Not
available
Naphtha (petroleum),
hydrotreated heavy Inhalation respiratory irritation Some positive data exist, but the
data are not sufficient for
classification NOAEL Not
available
Naphtha (petroleum), Inhalation nervous system Some positive data exist, but the Dog NOAEL 6.5 4 hours