Q3 Innovations DrugHAWK ECO Cup - Manual (Page 5)

Tetracycline
Tetrahydrocortisone 3-acetate
Tetrahydrocortisone 3 (b-D-glucuronide)
Tetrahydrozoline
Thiamine
Thioridazine
D/L-Tyrosine
Tolbutamide
Triamterene
Trifluoperazine
Trimethoprim
Tryptamine
D/L-Tryptophan
Tyramine
Uric acid
Verapamil
Zomepirac
O-Hydroxyhippuric acid
p-Hydroxyamphetamine
p-Hydroxytyramine
Ibuprofen
Iproniazid
D/L-Isoproterenol
Isoxsuprine
Ketamine
Ketoprofen
Labetalol
Loperamide
Meperidine
Meprobamate
Methoxyphenamine
Methylphenidate
Nalidixic acid
Naloxone
Naltrexone
Naproxen
Niacinamide
Nifedipine
Norethindrone
D-Norpropoxyphene
Noscapine
D/L-Octopamine
Oxalic acid
Oxolinic acid
Oxymetazoline
Papaverine
Penicillin-G
Pentazocine hydrochloride
Perphenazine
Phenelzine
Trans-2-phenylcyclo-propylamine hydrochloride
L-Phenylephrine
ß-Phenylethylamine
Phenylpropanolamine
Prednisolone
Prednisone
D/L-Propranolol
D-Propoxyphene
D-Pseudoephedrine
Quinacrine
Quinine
Quindine
Ranitidine
Salicylic acid
Serotonin
Sulfamethazine
Sulindac
Acetaminophen
Acetophenetidin
N-Acetylprocainamide
Acetylsalicylic acid
Aminopyrine
Amoxicillin
Ampicillin
L-Ascorbic acid
Apomorphine
Aspartame
Atropine
Benzilic acid
Benzoic acid
Benzphetamine*
Bilirubin
D/L-Brompheniramine
Caffeine
Cannabidol
Chloralhydrate
Chloramphenicol
Chlorothiazide
D/L-Chloropheniramine
Chlorpromazine
Chloroquine
Cholesterol
Clonidine
Cortisone
L-Cotinine
Creatinine
Deoxycorticosterone
Dextromethorphan
Diclofenac
Diflunisal
Digoxin
Diphenhydramine
Ecgonine methyl ester
L -Ψ-Ephedrine
b-Estradiol
Estrone-3-sulfate
Ethyl-p-aminobenzoate
[1R,2S] (-) Ephedrine
L(–)-Epinephrine
Erythromycin
Fenoprofen
Furosemide
Gentisic acid
Hemoglobin
Hydralazine
Hydrochlorothiazide
Hydrocortisone
Effect of Urinary Specific Gravity
Fifteen (15) urine samples of normal, high, and low specific gravity ranges (1.005, 1.015, 1.03) were
spiked with drugs at 50% below and 50% above cut-off levels respectively. The ECO CUP™ One
Step Drug Test was tested in duplicate using ten drug-free urine and spiked urine samples. The
results demonstrate that varying ranges of urinary specific gravity do not affect the test results.
Effect of the Urinary pH
The pH of an aliquoted negative urine pool was adjusted to pH ranges of 4.0 ,4.5, 5.0, 6.0 and 9.0,and
spiked with drugs at 50% below and 50% above cut-off levels. The spiked, pH-adjusted urine was
tested with the ECO CUP™ One Step Drug Test . The results demonstrate that varying ranges of
pH do not interfere with the performance of the test.
Cross-Reactivity
A study was conducted to determine the cross-reactivity of the test with compounds in either drug-free
urine or drug positive urine containing Cocaine, Barbiturates, Benzodiazepines, Amphetamine,
Methamphetamine, Marijuana, Methadone, MDMA (Ecstasy), Opiates, Oxycodone, Phencyclidine or
Tricyclic Antidepressants. The following compounds show no cross-reactivity when tested with The
ECO CUP™ One Step Drug Test at concentrations of 100.µg/mL.
Non Cross-Reacting Compounds
*Parent compound only; metabolizes into amphetamine and methamphetamine in the body.
BIBLIOGRAPHY
1. Stewart DJ, Inaba T, Lucassen M, Kalow W. Clin. Pharmacol. Ther. April 1979; 25 ed: 464, 264-8.
2. Ambre J. J. Anal. Toxicol. 1985; 9:241.
3. Hawks RL, CN Chiang. Urine Testing for Drugs of Abuse. National Institute for Drug Abuse (NIDA), Research
Monograph 73, 1986.
4. Tietz NW. Textbook of Clinical Chemistry. W.B. Saunders Company. 1986; 1735.
5. FDA Guidance Document: Guidance for Premarket Submission for Kits for Screening Drugs of Abuse to be Used
by the Consumer, 1997.
6. Robert DeCresce. Drug Testing in the workplace, 114.
7. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 2nd Ed. Biomedical Publ., Davis, CA 1982; 487.
8. OSHA, The Bloodborne Pathogens Standard 29, Code of Federal Regulations 29 CFR 1910.1030.
9. CDC, Centers for Disease Control (CDC) Guidelines, Morbidity and Mortality Weekly Report, Volume 37, Number
24, 1988.
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