MEGUIAR'S D115 - Manual (Page 7)

D115, Rinse Free Express Wash N’Wax (24-97C): D11501, D11505
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Page: 7 of 11
(4 hours)
1-propoxypropan-2-ol Ingestion Rat LD50 2,500 mg/kg
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Rabbit LD50 87 mg/kg
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Inhalation-
Dust/Mist
(4 hours) Rat LC50 0.33 mg/l
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat LD50 40 mg/kg
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
1-propoxypropan-2-ol Rabbit Minimal irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
Siloxanes and silicones, di-Me Rabbit No significant irritation
1-propoxypropan-2-ol Rabbit Severe irritant
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
1-propoxypropan-2-ol In Vitro Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
1-propoxypropan-2-ol Inhalation Some positive developmental data exist, Rat NOAEL 3.6 during