MEGUIAR'S MC201 - Manual (Page 7)

MC201, Motorcycle Detailer (20-171B): MC20108
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2H-isothiazol-3-one
ATE = acute toxicity estimate
Skin Corrosion/Irritation
Name Species Value
1-propoxypropan-2-ol Rabbit Minimal irritation
Propane-1,2-diol Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Serious Eye Damage/Irritation
Name Species Value
1-propoxypropan-2-ol Rabbit Severe irritant
Propane-1,2-diol Rabbit No significant irritation
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Rabbit Corrosive
Skin Sensitisation
Name Species Value
Propane-1,2-diol Human Some positive data exist, but the data are not
sufficient for classification
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Sensitising
Photosensitisation
Name Species Value
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one Human
and
animal Not sensitizing
Respiratory Sensitisation
Name Species Value
Germ Cell Mutagenicity
Name Route Value
1-propoxypropan-2-ol In Vitro Not mutagenic
Propane-1,2-diol In Vitro Not mutagenic
Propane-1,2-diol In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In vivo Not mutagenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-
one In Vitro Some positive data exist, but the data are not
sufficient for classification
Carcinogenicity
Name Route Species Value
Propane-1,2-diol Dermal Mouse Not carcinogenic
Propane-1,2-diol Ingestion Multiple
animal
species Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Dermal Mouse Not carcinogenic
Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-
2H-isothiazol-3-one Ingestion Rat Not carcinogenic
Reproductive Toxicity
Reproductive and/or Developmental Effects
Name Route Value Species Test result Exposure
Duration
1-propoxypropan-2-ol Inhalation Some positive developmental data exist, Rat NOAEL 3.6 during